Signaling Cell Based Therapy  

The Regenerative Medicine Clinic

Orthopaedic Surgeon & Molecular Immunobiologist located in Wilmington, NC

If you’re suffering from a joint injury, arthritis, joint pain, or a degenerative condition that isn’t getting better with traditional medicine, you may want to consider signaling cell therapy (stem cell therapy). At The Regenerative Medicine Clinic, regenerative Austin Yeargan III MD, takes a simple and natural approach and offers signaling cell therapy to heal many musculoskeletal conditions. To learn more about immunobiologics and how it may benefit you, call the office in Wilmington, North Carolina, or click the online booking button. Telemedicine appointments are also available for consultations.

Signaling Cell Therapy (Autologous Stem Cell Therapy)

What is the benefit of Autologous Signaling Cell Based treatment?

Signaling Cell injections are primarily for painful joints. These injections, provide a non-invasive (non-surgical) treatment option, to provide long-lasting relief from chronic joint pain. The injections are performed under ultrasound guidance, as needed, to ensure proper placement of the stem cells. Can also be used for chronic tendonitis, some meniscal tears, muscle strains, ligament sprains, some cartilage injuries, limited rotator cuff tears and fractures that fail to heal.

Signaling cell therapy involves the injection of a controlled amount of stem cells into your damaged tissue or joint to facilitate and expedite the healing process and restore tissue strength and function, without the need for surgical intervention.

Who is a candidate for this treatment? 

In general, injections are advised for moderate osteoarthritis in the hip, knee, shoulder, ankle, or thumb, where there is not complete collapse of the joint space and not “bone on bone” changes. There are some medical issues (like lymphoma and leukemia) that will preclude you from having an autologous cell based procedure.

Who is not a candidate for Signaling Cell Therapy?

  • Patient with cancer history (such as prostate cancer or breast cancer), not in remission for at least 5 years
  • Certain other malignancies or blood borne diseases that you are being treated for
  • Patient with any current infection
  • Patient who uses a high dose of coumadin
  • General procedural contraindication
  • Patients with multiple medical issues may not be good candidates (low testosterone, low vitamin D, hypothyroidism, diabetes, smoker).

This a partial list; there are other conditions that may limit your candidacy.

Which joints / body parts can stem cells be applied to?

We most commonly use signaling cell injections for joints such as hips and knees but also treat shoulders, ankles, great toes and thumbs. Cell based treatment is also an option for chronic tendon issues that have been resistant to other treatments. These are typically in the elbow and Achilles tendon.

What is the cost?

The final cost of this treatment will ultimately be determined by what particular injections are being done. The cost can vary by individual problem, but it is not inexpensive. Fortunately, there are financing options that make the procedure within reach of just about everyone.

Signaling Cell therapy is typically not covered by your insurance company. If you decide you want to explore this treatment option, you will first speak with one of our financial counselors. He or she will work with you to determine if your insurance will pay or if you will need to pay out of pocket for the treatment.

Where is this treatment offered?

Our physicians only provide treatment in Wilmington, NC at the Regenerative Medicine Clinic of Wilmington. All of our orthobiologic procedures are FDA cleared for safety and we strictly adhere to recommendations from the FDA Center for Biologics.

What should I do if I think I’m a candidate?

If you live within 3 hours of Wilmington, we will schedule a consultation for an appointment to review your radiology films (x-rays), conduct a physical exam, and determine if you are a good candidate or not.

If you live more than 3 hours away, please work with your local health care professional to send us the following:

  • Recent x-rays, no more than a few months old, are required. Please see below for the type of x-ray views needed for the effected body parts.
    Hip – Standing AP pelvis and frog lateral
    Knee – Standing bilateral AP and lateral
    Ankle – Standing AP, lateral and oblique
    Shoulder – Grashey and axillary lateral
    Thumb – AP, lateral and oblique
  • Recent MRI if available, no more than a few months old
  • Medical records (only pertaining to your injury that you are seeking treatment for)

Send your images and records to us for review – please include your name, address, phone number and email address. We will contact you with our recommendation with in 7-14 business days of receiving your records.


Where do the Mesenchymal stem cells come from?

Bone marrow is the source of stem cells that we use. The cells are harvested with a simple aspiration performed in out clinic. We harvest the bone marrow stem cells (called BMAC) from the anterior iliac crest at the thick portion called the gluteal pillar.

Will the procedure regenerate cartilage in my joint?

There is some limited data suggesting an ability to regenerate cartilage in joints, but it also appears that whether or not the cartilage regenerates has little correlation with relief of pain. If there is significant spurring and significant loss of the joint space, there is little chance of cartilage regeneration.

What is the success rate of Signaling Cell Based Therapy?

Our experience is that most patients will have significant relief of pain around 1-2 months post injection. This will often continue to improve for the first 3-6 months after the signaling cell procedure. There are patients who will not get any improvement at all from this procedure, probably around 10-20%. This is still an emerging hi-tech treatment, and there have not been a lot of long term outcomes studies done so far so we are still figuring out who is an ideal candidate to have this done.

Does the treatment consist of one injection or multiple injections?

Typically, we do one signaling cell injection that may be followed up 6 weeks later with a platelet rich plasma injection. All cases are individualized and many components of your care will be taken into consideration and may be modified as your treatment progresses. Our scientific protocols are continually evolving, so this is ultimately decided on a case-by-case basis.

Can I fly / drive home that day?

If you are flying (and you are not the pilot), you may fly home the same day, but there will be increased pain/discomfort after the procedure. If you are driving, you should have a driver, as there can be some mild to moderate discomfort in the first few hours following the procedure.

Dr. Yeargan monitors your progress and healing following your injection. In most cases, only one signaling cell therapy treatment is needed to get the best results.

To schedule a consultation to learn how stem cell therapy can help your musculoskeletal condition, contact The Regenerative Medicine Clinic by phone