Our treatments are based solely on our own intellectual property and have evolved based on our prospectively collected patient outcomes analysis data and they work. We’re not just copying what everyone else does. In fact, the field of regenerative orthopedic surgery started with us right here in Wilmington in 2006, almost 15 years ago, so this isn’t new to us. We’re leading the way, not playing catch up. It’s no wonder that over 900 clinics in the country now claim to do what we did first. We don’t sell unregulated off the shelf products that have no indication or value. At the very least we can educate you on what’s real, what might be real and what’s not possible when it comes to the discipline of orthopedic immunobiologics. The only concentrated stem cell product available in the United States today, comes from bone marrow, no fat, not amnionic fluid, not umbilical cord products, nothing but marrow.
When we say YOU. 100 percent, we mean it. From your signaling cells that are harvested from your bone marrow during a virtually bloodless and painless procedure, to the proprietary nanoplastic cellular product we deliver, everything is derived from you. We eliminate pro-inflammatory nanomolecules and replace them with anti-inflammatory and healing and growth factors that interact with the signaling cells that are delivered and in the native tissue. We use your own thrombin that we capture in a special procedure that other clinics just don’t do.
Basically, it works like this. Cells signal other cells in the region when there’s an issue that needs to be taken care of. Some cells come to help and then those cells call other cells to the area. Based on the signals they are receiving; the cells make proteins that are used for either rebuilding or more signaling. When there’s a big problem and a lot to heal, there’s a lot of complex signaling that goes on. Scientifically, we’re really figuring it out quickly and it’s all fascinating. (PUT ILLUSTRATION HERE)
The immune system oversees what goes on in the body and keeps us from harm and injury. It does that through cellular signaling called immunomodulation. Immune cells line the knee and are called monocytes. In fact, 15% of the cells lining the knee are this type of cell and respond with an inflammatory/healing cascade when activated by tiny parts of the cartilage matrix breaking apart.
Whenever the joint breaks down from overload, small pieces of the matrix the cartilage cells are in will degrade. These small nanomolecules collect in the joint fluid and irritate the inflammatory cells. They know something’s gone wrong, so a healing response is generated. When this healing response called inflammation goes on too long, usually more than two years, is when the brain decides the joint has wasted enough energy in the futile process and the joint is destroyed in favor of fusion rather than regeneration.
This is a critically important concept to grasp. Inflammation IS healing! That’s a key concept because without inflammation, there is no healing. So, the healing response IS the inflammatory response. We just have to control it.
Inflammation, (or healing remember!) occurs in three phases.
PHASE 1: The PRO-INFLAMMATORY PHASE
The first phase, or the inflammatory phase occurs when an alarm is set off because something is not right. For our discussion, since we’re talking about arthritis, we’re talking about cartilage overload and subchondral bone stiffening. With matrix destruction due to overload that exceeds the endurance limit of the tissues, synovial lining cells begin to release inflammatory molecules to clean up and prepare the damaged surfaces for the second phase of the inflammatory (healing) response. Specific molecules released aren’t important to know, but include IL-1B, TNF-a, MMP-13, IL-6, IL-8, LIF and many others. These are all pro-inflammatory molecules that do some damage each time they are released. They are all quite small due to the need for them to be able to snuggle into the small areas where the damage is greatest.
I should stop and point out that it is because these pro-inflammatory molecules are quite small that we are able to exclude them from the plasma that we collect from your bone marrow. We use a special nanofilter that has a pore size just large enough to let all of the pro-inflammatory molecules get out so that we are able to concentrate JUST the anti-inflammatory and healing and growth factors that are desirable for the signaling cell treatments. We do something that no one else does too. We concentrate TSG-6, the most important chondroprotective molecule that gets lost in everyone else’s signaling cell product, making ours the most advanced stem cell treatment in the world, but that’s not all we do that’s unique.
So what cells are making these pro-inflammatory and anti-inflammatory molecules for inflammation and healing? Right. IMMUNE system cells. Other cells in the joint are involved too, like cartilage cells, bone cells and resident tissue cells. Arthritis is an organic process that involves the whole joint, not just the cartilage and primarily the bone underneath the cartilage, where arthritis starts.
PHASE 2: The REPAIR and REGENERATION PHASE:
Phase two is the phase we are trying to amplify with our signaling cell transplant procedures and is the most important when it comes to your chances of healing broken tissues in an arthritic joint. Naturally, this phase of inflammation (healing) comes after the pro-inflammatory molecules have dropped in concentration. The job of preparing the site has been completed.
In this phase, the immune cells and other involved cells begin to release anti-inflammatory and healing molecules and growth factors that cause an anabolic response in the tissues that favors a regenerative state. Basically, the procedure converts a previously catabolic joint that was in the midst of breaking down, into an anabolic environment that favors healing, repair and regeneration. That’s why phase two is called the repair and regeneration phase. This phase continues for varying lengths of time, depending on how much damage needs to be repaired and regenerated. Generally, it takes six weeks for any biological tissue to regain its compressive and tensile strength and remodeling continues from 6 weeks to 24 months.
PHASE 3: THE REMODELING PHASE
Phase three is the remodeling phase and generally lasts about two years in human tissues. More specialized cells take place in this process and different types of signaling molecules, many from the TGF-B family are involved. Resident signaling cells, often referred to as mesenchymal stem cells, medicinal signaling cells or adult stem cells can be found in niches in every tissue in the human body, including the brain (SVZ). These resident stem cells are responsible for cellular and tissue renewal and maintenance. How do they work? Signaling cascades, of course!
Just like humans do every day, cells tell each other what is needed and what is wanted. Cells work hard to keep their tissues functional and working with other tissues. Remodeling occurs if there is cellular fuel called ATP to maintain the process. It doesn’t matter how old you are, your signaling, or stem cells, are just as lively when you’re 9 as when you’re 90, you don’t have as many, but you certainly have enough for a signaling cell transplant, that’s been conclusively demonstrated by George Muschler MD at the Cleveland Clinic, one of the most respected orthopedic surgeons and immunobiologists in the country. (Muschler, JBJS, 2004). Put a link to these articles here:
Make link say:Optimizing Assays of Human Stem Cells in Bone Marrow
MAKE LINK SAY: PRINCIPLES OF CLINICL CELL BASED TISSUE ENGINEERING
MAKE LINK SAY: DECREASED PROGENITOR CELLS WITH AGING IS NO FACTOR WHEN COMPARING BIOLOGICAL POTENTIAL DURING OSTEOARTHRITIC DISEASE PROGRESSION
(MAKE IT SO THE LINK READS
Phase three generally lasts two years but cellular turnover in all tissues continues indefinitely.