Low intensity pulsed ultrasound delivers a lower than traditional ultrasound frequency (<3W/cm3) that activates human cell mechanical receptors and enhances cartilage tissue regeneration. Activation of these mechanoreceptors affects cartilage cell matrix production. This occurs through defined integrin mediated p38 Mitogen Associated Protein Kinase (MAPK) immunologic signaling cascades. Low intensity pulsed ultrasound promotes cartilage repair in osteoarthritis. It is believed that LIPUS enhances cartilage cell matrix production, division and differentiation through other spatiotemporally related signaling pathways as well, including the Rho/ROCK/Src/ERK pathway.

LIPUS has been used therapeutically in rehabilitation medicine and over the last decade has been found to have a range of biologically anabolic effects on tissues including promoting fracture healing, accelerating soft tissue regeneration and inhibiting the inflammatory response, all operative in osteoarthritis. Due to the low intensity and pulsed output mode, LIPUS has minimal thermal effects. Non-thermal effects have been claimed to produce therapeutic tissue changes in several studies.

While LIPUS is not as useful as a standalone treatment modality, we believe it has application in our Nanoplasty procedures and have decided to make it a part of our clinical treatment algorithm at no additional cost to the first 50 patients to enroll in our marquis signaling cell NAMAD® procedure with microcore technology.

Our procedure attacks arthritis where it starts, in the subchondral bone. Making nanoplastic alterations at the molecular level leads to structural and functional changes that are reflected in the clinical relief of symptoms our patients enjoy for years. Using accurate and validated outcomes analyses, we intend to determine whether or not the addition of LIPUS as a therapeutic advantage makes a difference in your treatment, we’re willing to bet it does.

S. Austin Yeargan III, MD Orthopedic Surgeon Molecular Immunobiologist

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