Inflammation is healing


Our treatments are based solely on our own intellectual property and have evolved based on our prospectively collected patient outcomes analysis data. We don’t sell unregulated off the shelf products that have no indication or value. At the very least we can educate you on what’s real, what might be real and what’s not possible when it comes to the discipline of orthopedic immunobiologics.

When we say YOU. 100 percent, we mean it. From your signaling cells that are harvested from your bone marrow during a virtually bloodless and painless procedure, to the proprietary nanplastic cellular product we deliver, everything is derived from you. We eliminate pro-inflammatory nanomolecules and replace them with anti-inflammatory and healing and growth factors that interact with the signaling cells that are delivered and in the native tissue.

Basically, it works like this. Cells signal other cells in the region when there’s an issue that needs to be taken care of. Some cells come to help and then those cells call other cells to the area. Based on the signals they are receiving, the cells make proteins that are used for either rebuilding or more signaling. When there’s a big problem and a lot to heal, there’s a lot of complex signaling that goes on. Scientifically, we’re really figuring it out quickly and it’s all fascinating.

The immune system is in charge of what goes on in the body and keeps us from harm and injury. It does that through cellular signaling! Immune cells line the knee and are called monocytes. In fact, 15% of the cells lining the knee are this type of cell.

Whenever the joint breaks down from overload, small pieces of the matrix the cartilage cells are in degrade. These small nanomolecules collect in the joint fluid and irritate the inflammatory cells. They know something’s up so a healing response is generated.

So this is important. Inflammation IS healing! That’s a key concept. Without inflammation, there is no healing. So the healing response IS the inflammatory response. Very important. Inflammation, (or healing remember!) occurs in three phases.


The first phase, or the inflammatory phase occurs when an alarm is set off because something is not right. For our discussion, since we’re talking about arthritis, we’re talking about cartilage overload and subchondral bone stiffening. With matrix destruction due to overload that exceeds the endurance limit of the tissues, synovial lining cells begin to release inflammatory molecules to clean up and prepare the damaged surfaces for the second phase of the inflammatory (healing) response. Specific molecules released aren’t important to know, but include IL-1B, TNF-a, MMP-13, IL-6, IL-8, LIF and many others. These are all pro-inflammatory molecules that do some damage each time they are released. They are all quite small due to the need for them to be able to snuggle into the small areas where the damage is greatest. I should stop and point out that it is because these pro-inflammatory molecules are quite small that we are able to exclude them from the plasma that we collect from your bone marrow. We use a special nanofilter that has a pore size just large enough to let all of the pro-inflammatory molecules get out so that we are able to concentrate JUST the anti-inflammatory and healing and growth factors that are desirable for the signaling cell treatments. So what cells are making these pro-inflammatory and anti-inflammatory molecules for inflammation and healing? Right. IMMUNE system cells.


Phase two is the phase we are trying to amplify with our signaling cell transplant procedures and is the most important when it comes to your chances of healing broken tissues in an arthritic joint. This phase of inflammation (healing) comes after the pro-inflammatory molecules have dropped in concentration. The job of preparing the site has been completed. In this phase, the immune cells begin to release anti-inflammatory and healing molecules and growth factors that cause an anabolic response in the tissues that favors a regenerative state. Basically, the procedure converts a previously catabolic joint that was in the midst of breaking down, into an anabolic environment that favors healing, repair and regeneration. That’s why phase two is called the repair and regeneration phase. This phase continues for varying lengths of time, depending on how much damage needs to be repaired and regenerated. In general it takes six weeks for any biological tissue to regain its compressive and tensile strength.


Phase three is the remodeling phase and generally lasts about two years in human tissues. More specialized cells take place in this process and different types of molecules, many from the TGF-B family are involved. Resident signaling cells, often referred to as mesenchymal stem cells can be found in niches in every tissue in the human body, including the brain. These resident stem cells are responsible for cellular and tissue renewal and maintenance. How do they work? Signaling cascades, of course!

Just like humans do every day, cells tell each other what is needed and what is wanted. Cells work hard to keep their tissues functional and working with other tissues. Remodeling occurs as long as there is cellular fuel to maintain the process. It doesn’t matter how old you are, your signaling, or stem cells, are just as lively when you’re 9 as when you’re 90, you don’t have as many, but you certainly have enough for a signaling cell transplant, that’s been conclusively demonstrated by George Muschler MD at the Cleveland Clinic, arguably the most respected orthopedic surgeon and immunobiologist in the country.

Phase three generally lasts two years but cellular turnover in all tissues continues indefinitely.

S. Austin Yeargan III, MD Orthopedic Surgeon Molecular Immunobiologist

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