Blog Archive

Regenerative Medicine vs. Health Insurance Mar 24th, 2020

Why Insurance Won’t Pay for Orthobiologics S. Austin Yeargan III, MD We really are a “Regenerative Medicine” Clinic and that’s why we were the first in the country to arrive at the conclusion that the name “Regenerative Medicine” would be ideal for our practice. To this day, there is no...

Nanomolecular Level Mar 23rd, 2020

Why do you call your procedure the Yeargan “Nanoplasty”? What’s so special about your procedure? Why isn’t it the most expensive if yours is the best?   The cell based treatment (CBT) we use for marrow based autologous transplant in the treatmet of arthritis is called the Nanoplasty procedure. We...

The Mechanotransduction Theory Mar 23rd, 2020

The mechanotransduction Theory   Austin Yeargan III MD If you live long enough, you get cancer. While the mechanisms are different, the same is true for arthritis, particularly if your lower extremity alignment isn’t perfect. There are two components where the genesis of arthritis is concerned. While they are very...

A Physical Therapy Algorithm in the Setting of Orthopaedic Immunobiologics for Unicompartmental Knee Mar 23rd, 2020

A Physical Therapy Algorithm in the Setting of Orthopeadic Immunobiologics for Unicompartmental Knee Osteoarthritis Signaling cell treatments, often referred to erroneously as “stem cell treatments” and “regenerative therapies” are not uniform between clinics and often do not even represent scientifically justified management strategies. In fact, a recent article in the...

TSG-6 Mar 23rd, 2020

Is TSG-6 the most important biomolecule in orthopedic molecular immunobiologics? Austin Yeargan III MD Background: Bone marrow concentrates for knee arthritis have received much attention over the last decade as a viable treatment for osteoarthritic knee pain and disability.  In spite of the availability of these bone marrow concentrates, there...

Nanoplasty or Nothing Mar 23rd, 2020

If it’s not the Nanoplasty, you’re stem cell therapy is just for the treatment of arthritis pain. Only procedures that address the bone underneath the cartilage, where the arthritis starts, have the potential to halt or even reverse your arthritis. Cartilage restoration is a big part of the Nanoplastytm and...

How could adult medicinal signaling (stem) cells make a difference in COVID-19? Mar 23rd, 2020

Transplantation of ACE2- Mesenchymal Stem Cells Improves the Outcome of Patients with COVID-19 Pneumonia In these types of viral conditions, the immune system is exposed to a large antigen load that over activates the inflammatory/healing signaling cascade through T cell major histocompatibility complex (MHC) I and II proteins. This overactivation...

Adenosine Triphosphate - ATP Mar 22nd, 2020

ATP Two big types of cells occupy the knee joint cavity.  One type is called synovial cells and there are two kinds.  Together, these synovial cells are called ‘synoviocytes’.  Type A synoviocytes number about 20% of the lining cells.  The rest are fibroblast progenitor cells or type B synovial cells....

Rooster Comb Injections for the Knee Osteoarthritis Mar 20th, 2020

Viscosupplementation treatments of the knee are very reasonable, scientific treatments for knee pain. These injections are covered by most insurance policies for arthritic knee pain every six months and are easily performed in the clinic setting with very little pain. While not specifically indicated for other human joints, the principles...

The Anti-Inflammatory Diet Mar 17th, 2020

Including Anti-Inflammatory Foods in your Diet   Austin Yeargan III MD Brittany LaRussa BS   Regenerative Medicine Clinic, 5425 Oleander Drive, Wilmington, NC 28403.  Keep in my everybody is different, and what works for one person may not work for the next person which is why you should take the...

What else is there for arthritis besides the Nanoplasty? What's Wharton's Jelly good for? Mar 15th, 2020

What else is there for arthritis besides the Nanoplastytm? What’s Wharton’s Jelly good for? How long will that last?   Austin Yeargan III MD   Arthritis Treatments are either catabolic or anabolic.  Wharton’s Jelly is an anabolic treatment that is now offered in regenerative medicine clinics across the nation amid...

Biologic shots: Stem cell injections (bone marrow signaling cell) Mar 10th, 2020

Biologic shots: Stem cell injections (bone marrow signaling cell) and Treatments for Knee pain and Arthritis-How and why they work. Austin Yeargan III MD   No therapy is currently available to completely prevent the initiation or progression of organic joint disease partly due to poor understanding of the mechanisms of...

Inflammation is healing Mar 9th, 2020

  Our treatments are based solely on our own intellectual property and have evolved based on our prospectively collected patient outcomes analysis data. We don’t sell unregulated off the shelf products that have no indication or value. At the very least we can educate you on what’s real, what might...

Autologous Biologics and Molecular Medicine Mar 5th, 2020

  Autologous Biologics and Molecular Medicine: The clinical translation of cellular and molecular biotechnology to applications in orthopedic surgery from Hippocrates until 2018.   The clinical experience with signaling cell therapies and molecular medicine in orthopedic surgery   Austin Yeargan III MD   Abstract: We had little to go on...

Endocannabinoids in Orthopedic Surgery and Musculoskeletal Medicine: Is it Time for a Green Standard Mar 5th, 2020

https://www.ecronicon.com/ecor/pdf/ECOR-11-00592.pdf   Abstract Keywords: Endocannabinoids; Orthopedic Surgery; Musculoskeletal Medicine; Cannabis Cannabis and endocannabinoid agonists have been safely used for decades by a large segment of the United States population for both recreational and medicinal purposes [1]. The medical use of cannabis products has been legislatively restricted for decades in the...

The Biogenic Inflammatory Theory Mar 2nd, 2020

Where does arthritis come from? The biogenic inflammatory theory.  Nanoplasty with Subarticular MicroCore† technology   Austin Yeargan III MD   Arthritis is a mechanical disease with predictably sinister nanomolecular consequences.  Once the applied load to the cartilage surfaces exceeds the mechanical properties of the cartilage and the proteoglycan cartilage matrix,...

Cell Biology Basics Feb 23rd, 2020

Cell Biology Basics Humans are made of many different types of cells that are specialized to do a specific job, based on environmental demands in the niche that they occupy. The body human contains approximately 37.2 trillion cells. This is a number that is very difficult for humans to process...

Why do we take an extra step to use your clotting proteins instead of cow proteins? Feb 23rd, 2020

Why do we take an extra step to use your clotting proteins instead of cow proteins for signaling cell procedures? Why do we use calcium to pop open platelets? Do you have to do that?   Modern, advanced signaling cell procedures include construction of a customized autologous fibrin scaffold for...

LIPUS Feb 20th, 2020

Low intensity pulsed ultrasound delivers a lower than traditional ultrasound frequency (<3W/cm3) that activates human cell mechanical receptors and enhances cartilage tissue regeneration. Activation of these mechanoreceptors affects cartilage cell matrix production. This occurs through defined integrin mediated p38 Mitogen Associated Protein Kinase (MAPK) immunologic signaling cascades. Low intensity pulsed...

Signaling Cell or Stem Cell Feb 17th, 2020

What’s the problem with signaling cell therapy (what others are calling stem cell treatments)?   Austin Yeargan III MD   Put quite simply, it’s the doctors.   All physicians, not just orthopedic surgeons must put their profession and their patients above self.  In the setting of orthobiologics, this has been...

Arthritis is not a disease of the cartilage itself, but a disease of the subchondral bone beneath. Feb 10th, 2020

TSG6 is the only biochemical with a chondroprotective designation. This serine protease inhibitor may be the key to cartilage restoration science and for that reason we concentrate it using a proprietary processor while strictly adhering to FDA guidelines for biologic treatments. Our growth factor concentrate product, GFC6, forms the basis...

Where does osteoarthritis come from? Feb 10th, 2020

What is YOUNG’s Modulus? Why is it important? Where does osteoarthritis come from? Austin Yeargan MD Regenerative Medicine Clinic, Wilmington, North Carolina Young’s modulus measures the amount of elasticity of a material. You may see it referred to as just ‘Young’s modulus’ or ‘Young’s modulus of elasticity’. Elasticity, or stiffness,...

Why doesn’t Platelet Rich Plasma PRP work for arthritis? What’s it good for? Is it good for anything Jan 27th, 2020

Why doesn’t Platelet Rich Plasma PRP work for arthritis? What’s it good for? Is it good for anything? Austin Yeargan III MD In this setting of cell transplant procedures, which do work by virtue of the signaling cell fraction, the easiest analogy to make is to a recipe for clam...

Magnetic Resonance Cartigram Sequencing in the Setting of Autologous Orthopedic Immunobiologics Jan 24th, 2020

  ecronicon.com/ecor/pdf/ECOR-11-00577.pdf Abstract Diffusion weighted MRI Sequencing (DWI) has the capability to diagnose arthritic joint disease and degenerative disk disease (DDD) earlier than any other imaging modality. These studies are ideal for the early detection of joint pathology due to arthritis and spondylosis. Earlier detection of biochemical and structural changes...

What’s the problem with signaling cell therapy (what others are calling stem cell treatments)? Jan 23rd, 2020

Put quite simply, it’s the doctors. All physicians, not just orthopedic surgeons must put their profession and their patients above self. In the setting of orthobiologics, this has been the very rare exception. Tricky marketing aimed at fooling patients into believing you’re an orthopedic surgeon or real sports medicine surgeon...

Leadership and Responsibility to Teach Jan 16th, 2020

Leadership and the Responsibility to Teach   We have a lot of people who are interested in what we are doing.  We have surgeons visiting from the United States and all over the world who want to learn our technique.  We try to hand pick only the best candidates and...

Athletic Shoes; The Right Fit for You Jan 14th, 2020

Athletic Shoes; The Right Fit for You     When it comes to buying a pair of athletic shoes, it’s easy to go with the top selling brand or read about what others recommend based on their experience. However, what most people fail to understand is how everyone has different...

PRP Still Struggles For An Indication Jan 1st, 2020

New research observed no benefit from the use of platelet-rich plasma (PRP) injection in patients with acute Achilles tendon rupture. “Despite 37 clinical trials on applications of platelet rich plasma in musculoskeletal injuries so far, its efficacy remains uncertain,” the researchers wrote. “These trials, and the two previous trials of...

Orthopedic Immunobiologics: A Gold Standard for Management in Organic Joint Pain Dec 18th, 2019

Orthopedic Immunobiologics: A Gold Standard for Management in Organic Joint Pain Austin Yeargan* Clinical Translation of Orthopedic Immunobiologics, Orthopedic Surgery Practice by a Small Lab in Wilmington, North Carolina, USA *Corresponding Author: Austin Yeargan, Clinical Translation of Orthopedic Immunobiologics, Orthopedic Surgery Practice by a Small Lab in Wilmington, North Carolina,...

Mesenchymal stem cells treating traumatic articular cartilage defects Dec 16th, 2019

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4289291/

Optimizing Clinical use of Biologics; excerpt in American Academy of Orthopedic Surgeons Journal Dec 13th, 2019

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6314629/

Arthritic Knee Pain Dec 11th, 2019

Managing Joint arthritis and in particular knee joint arthritis without surgery is what we do best and we do it without surgery the majority of the time. Our orthopedic surgeon is also a trained molecular chemist and immunologist. Doctor Yeargan is a key opinion leader and the original pioneer of...

Wilmington Business Journal Feb 11th, 2019

http://www.wilmingtonbiz.com/health_care/2017/08/25/yeargan_uses_patients_own_cells_to_heal/16477

Adult stem cells used to aid recovery after surgery Feb 9th, 2019

Adult stem cells used to aid recovery after surgery