Adenosine Triphosphate - ATP


Two big types of cells occupy the knee joint cavity.  One type is called synovial cells and there are two kinds.  Together, these synovial cells are called ‘synoviocytes’.  Type A synoviocytes number about 20% of the lining cells.  The rest are fibroblast progenitor cells or type B synovial cells.

Progenitor cells are cells on the way to becoming a specific type of cell.  In this case a fibroblast.  Fibroblasts are stem cells because they can divide into progeny (birth new cells) and specialize into different types of cells that have different jobs.  This process is called differentiation. So fibroblasts, or type B synoviocytes, maintain the cell population in the tissue by constantly surveilling and replacing senescent cells. 

These senescent cells collect and require removal by your immune system throughout the rest of your life and you can imagine that they start to collect like trash in alleyways.  Your immune system uses considerable energy eliminating these senescent cells.  That energy comes in the form of ATP, which is the fuel that drives all of our cells.

Because of the potential to preserve ATP, some authors have suggested that dietary supplements that help the body to eliminate these dead cells and their metabolites could be valuable in longevity medicine, more of a cult following than an actual medical field at this point.

Your body wants to preserve as much ATP it can for as long as it can.  When you’re out of ATP, your heart stops and your life ends.  That simple.

So you can see how much of a priority it MUST be for your brain to conserve ATP.  Your brain knows that it has a finite life. This becomes particularly true as you age. You become acutely aware of QTR around the age of fifty if you are educated, otherwise count on 70.  Neither matters.

Either way, saving ATP is a central theme that recurs throughout the lifetime of the sapien species.  ATP even has a role when discussing arthritis.  It’s a big role in fact.


S. Austin Yeargan III, MD Orthopedic Surgeon Molecular Immunobiologist

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